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  • Title: Anatomic Features of Head and Neck Keratinocyte Cancer in Virginia.
    Author: Karlin J, Engelhard S, Russell M, Kirzhner M.
    Journal: Dermatol Surg; 2020 Dec; 46(12):1486-1491. PubMed ID: 32205748.
    Abstract:
    BACKGROUND: Keratinocyte cancer (KC) patients benefit from early diagnosis. We describe here the anatomy of head/neck KCs to help guide screening efforts. OBJECTIVE: To examine lesion frequency and anatomic distribution of head and neck KC. METHODS: This retrospective cohort study of 4,770 consecutive pathology reports, 1998 to 2015, analyzes 5,463 head and neck KCs (3,664 basal cell carcinoma [BCC], 1,259 squamous cell carcinoma [SCC], and 540 SCC in situ) from 3,581 patients. RESULTS: Basal cell carcinoma relative tumor density (RTD) was highest on the nose; SCC RTD was highest on the cheek. Basal cell carcinoma-to-SCC ratio was highest on eyelid and lowest on scalp. Temple, ear, and neck SCC predominated in men; nose and cheek SCC in women. Scalp, temple, and ear BCC showed male predominance, while cheek, nose, and chin predominated in women. Left-sided ear SCC in situ and BCC were more common than right-sided ear lesions. CONCLUSION: This study demonstrates gender- and laterality-specific differences that comport with patterns of solar exposure.
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