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  • Title: Final height in a group of untreated children with constitutional growth delay.
    Author: Volta C, Ghizzoni L, Buono T, Ferrari F, Virdis R, Bernasconi S.
    Journal: Helv Paediatr Acta; 1988 Nov; 43(3):171-6. PubMed ID: 3220788.
    Abstract:
    We retrospectively evaluated the growth of 41 children with constitutional growth delay followed till adulthood and never treated with growth-promoting therapies. Final height has been correlated with prepubertal height, genetic target and height prediction calculated in both prepuberty and puberty. All patients showed a significant improvement of their height standard deviation score (HSDS) from prepuberty to adulthood, and the great majority of them achieved a final height above the 3rd percentile. Moreover, we found a good correlation between final height and both genetic target and height prediction, even if the latter overestimated final height in 25% of the patients. In conclusion, our data confirm that constitutional growth delay is a normal variant of growth. Therefore, caution should be paid in considering pharmacological treatment of this condition.
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