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  • Title: Is bone marrow biopsy a prognostic parameter in B-CLL?
    Author: Raphael M, Chastang C, Binet JL.
    Journal: Nouv Rev Fr Hematol (1978); 1988; 30(5-6):377-8. PubMed ID: 3222148.
    Abstract:
    Four hundred and ninety-three bone marrow biopsies from CLL patients were analysed on the basis of non diffuse versus diffuse bone marrow lymphocytic infiltration patterns. In each clinical stage A, B, and C there were non significant differences in survival rates according to the bone marrow pattern. However in stage A studying the evolution to stage B or C, a significant difference between patients with non diffuse and diffuse pattern was observed.
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