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  • Title: Rhodium(III)-Catalyzed Asymmetric C-H Activation of N-Methoxybenzamide with Quinone and Its Application in the Asymmetric Synthesis of a Dihydrolycoricidine Analogue.
    Author: Yan X, Zhao P, Liang H, Xie H, Jiang J, Gou S, Wang J.
    Journal: Org Lett; 2020 Apr 17; 22(8):3219-3223. PubMed ID: 32237753.
    Abstract:
    A chiral CpRhIII-catalyzed asymmetric C-H activation reaction of N-methoxybenzamides with quinones has been developed to efficiently forge chiral tricyclic hydrophenanthridinone scaffolds in ≤88% yield and ≤94% ee. With this methodology as the key step, an enantioenriched dihydrolycoricidine derivative has been synthesized in 64% overall yield in five steps.
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