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  • Title: [Intracellular Ca2+ homeostasis in the smooth muscle and functional role of calcium pump in the sarcolemma].
    Author: Kosterin SA, Kurskiĭ MD, Burchinskaia NF.
    Journal: Biofizika; 1988; 33(5):850-4. PubMed ID: 3224112.
    Abstract:
    It has been found that Ca-pump of the smooth muscle sarcolemma has much greater affinity to Ca2+ (Km = 0.5 M) than the system Na-Ca2+ of the exchanger (Km = 40-60 M). The maximal rate of Mg2+, ATP-dependent translocation of Ca2+ is 2-3 times higher than that of Na-dependent. The results of kinetic analysis show that Ca-pump of the smooth muscle sarcolemma is able to compensate the basal diffusion flow of this cation entering into unexcited cells of smooth muscle (5 x 10(-15) mol Ca2+ per 1 cm2 for 1 sec). It can also stationary support the value of Ca2+ concentration in relaxed myocytes on a physiologically significant level (10(-7)-10(-6) M).
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