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  • Title: Induction of hyperthyroidism in burn patients treated topically with povidone-iodine.
    Author: Rath T, Meissl G.
    Journal: Burns Incl Therm Inj; 1988 Aug; 14(4):320-2. PubMed ID: 3224302.
    Abstract:
    Hyperthyroidism was induced in two burn patients (one a 34-year-old male, with burns covering 80 per cent BSA and the other a 22-year-old female with a 45 per cent BSA burn) by topical treatment with povidone-iodine. Both patients had no history of thyroid disease and their post-burn examination revealed normal thyroid glands. In both patients 1 per cent povidone-iodine was applied onto granulation tissue and a marked increase in circulating thyroid hormones occurred. After topical treatment with povidone-iodine was discontinued circulating thyroid hormones returned to normal values within weeks. In the second patient povidone-iodine treatment had to be repeated again resulting in hyperthyroidism which was also readily reversible.
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