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  • Title: Role of alveolar macrophages in tumor-bearing rats: tumoricidal properties of carrageenan-activated macrophages.
    Author: Bijma AM, Stehmann TE, Weijma IM, Kort WJ.
    Journal: Invasion Metastasis; 1988; 8(6):364-73. PubMed ID: 3225148.
    Abstract:
    Tumor BN472, a malignant mammary adenocarcinoma, was subcutaneously transplanted into syngeneic female Brown Norway rats. Seven days after tumor inoculation, carrageenan-impregnated synthetic sponges were subcutaneously implanted in control and tumor-bearing rats. Another week later the animals were sacrificed and alveolar macrophages were harvested and tested for tumoricidal activity against a tissue culture line of BN472 cells and their capacity to phagocytose formaldehyde-treated sheep erythrocytes. The data demonstrate that carrageenan statistically significantly enhances the tumoricidal activity of alveolar macrophages in tumor-bearing rats. Phagocytic activity of the macrophages in these animals is not different from sham-operated control animals, whereas the phagocytic activity of tumor-bearing rats is statistically significantly decreased.
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