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  • Title: Vitamin C and post-suxamethonium pains.
    Author: Wood JB, Attwood EC, Wood BM, Dowling RM, Bradley F.
    Journal: Anaesthesia; 1977 Jan; 32(1):21-4. PubMed ID: 322529.
    Abstract:
    A double-blind trial of the effects of vitamin C on the frequency, severity and duration of post-suxamethonium pains was performed. Fifty-three patients undergone bronchoscopy received either a placebo or 10 g of vitamin C. No beneficial effect was demonstrated. In 18 patients no relationship was found between pre-anaesthetic buffy layer vitamin C levels and the subsequent pains. Measurement of buffy layer and plasma vitamin C levels before and after anaesthesia did not suggest that vitamin C deficiency occurs during or immediately after administration of suxamethonium. It is concluded that the administration of vitamin C cannot be recommended as a means for prevention of suxamethonium pains.
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