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  • Title: Core-shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro.
    Author: He L, Pang K, Liu W, Tian Y, Chang L, Liu X, Zhao M, Liu Y, Li Y, Jiang X, Song R, Liu Y.
    Journal: J Mater Chem B; 2019 Feb 21; 7(7):1050-1055. PubMed ID: 32254772.
    Abstract:
    Core-shell Au@zeolitic-imidazolate-framework-8 (ZIF-8) nanostructures are reported as a nanocarrier with both a high drug payload and high cancer treatment efficiency in vitro. Impressively, when used as multifunctional drug delivery vehicles, such core-shell Au@ZIF-8 nanostructures not only exhibit light- and pH-controlled drug release properties, but also provide two synergetic therapeutic modes for cancer treatment, resulting in 98% cell-killing activity after 30 min light irradiation followed by 24 h incubation even though HeLa cells are treated only by Au@ZIF-8 nanostructures loaded with 10 μM doxorubicin hydrochloride. All these results demonstrate the promising applications of this type of core-shell nanostructure in biomedical fields.
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