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  • Title: An amplification label of core-shell CdSe@CdS QD sensitized GO for a signal-on photoelectrochemical immunosensor for amyloid β-protein.
    Author: Feng J, Li F, Li X, Ren X, Fan D, Wu D, Ma H, Du B, Zhang N, Wei Q.
    Journal: J Mater Chem B; 2019 Feb 21; 7(7):1142-1148. PubMed ID: 32254782.
    Abstract:
    In this work, the heterostructures of Au nanoparticles loaded on 3D flower-like α-Fe2O3 (Au NPs/α-Fe2O3) as a platform and core-shell CdSe@CdS quantum dots sensitized graphene oxide (GO/CdSe@CdS QDs) as a signal amplification label were established in an ultrasensitive sandwich-type photoelectrochemical (PEC) immunosensor based on the "signal-on" type amplification method for detection of amyloid β-protein (Aβ). Specifically, the ultrahigh sensitivity of the proposed immunosensor came from two main properties. First, Au NPs/α-Fe2O3 could partially absorb visible-light, which dramatically promotes electron transfer because of the excellent conductivity of Au NPs, and effectively inhibits the electron-hole recombination, thanks to the effect of heterostructures. Second, the signal-on type is based on the signal amplification label of GO/CdSe@CdS QDs which on adequate absorption of visible-light can improve generation of photogenerated electron-hole pairs effectively. Under optimal conditions, the well-prepared PEC immunosensor exhibited a low detection limit of 0.02 pg mL-1 and a wide linear range from 0.06 pg mL-1 to 350 ng mL-1 for Aβ detection. Meanwhile, it also presented good reproducibility, specificity, and stability and might open a new promising pathway for detection of other important biomarkers.
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