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  • Title: Nasal decongestant activity of pseudoephedrine.
    Author: Roth RP, Cantekin EI, Bluestone CD, Welch RM, Cho YW.
    Journal: Ann Otol Rhinol Laryngol; 1977; 86(2 pt. 1):235-42. PubMed ID: 322570.
    Abstract:
    The effectiveness of orally administered pseudoephedrine in patients with acute or chronic nonsuppurative rhinitis was evaluated under double-blind conditions. Intranasally administered ephedrine which was given to all patients at the end of this study served as the positive control. Marked nasal decongestant effects of a single oral dose of pseudoephedrine (60 mg tablet), as determined by a modified passive anterior, rhinometric technique occurred within 30 minutes and were maintained for at least four hours. The mean nasal decongestant response (delta % of baseline) of 57.2% was associated with a mean peak, plasma pseudoephedrine level of 274 ng/ml. In addition, the maximum response to oral pseudoephedrine treatment was equivalent to the response produced by ephedrine nasal spray. These results suggest that pseudoephedrine is an orally, effective nasal decongestant.
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