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  • Title: In vitro effect of xipamide on sodium-potassium transport systems in human erythrocytes.
    Author: Lijnen P, Fagard R, Staessen J, Amery A.
    Journal: Methods Find Exp Clin Pharmacol; 1988 Aug; 10(8):527-30. PubMed ID: 3226221.
    Abstract:
    The in vitro effects of xipamide in a concentration range of 10(-8) to 10(-2) M were investigated on various Na+ and K+ transport systems in human red blood cells. Xipamide inhibited the anion carrier or DIDS-sensitive LiCO3- -influx starting from a concentration of 10(-5) M. However, a decrease in the Na+, K+-pump and the Na+, K+-cotransport activity and a rise in the passive permeability of the cell membrane was only observed starting from a concentration of 10(-4) M xipamide.
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