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  • Title: Electrochemical immunoassay for the carcinoembryonic antigen based on Au NPs modified zeolitic imidazolate framework and ordered mesoporous carbon.
    Author: Zhang Y, Zhang Z, Rong S, Yu H, Gao H, Ding P, Chang D, Pan H.
    Journal: Mikrochim Acta; 2020 Apr 08; 187(5):264. PubMed ID: 32270338.
    Abstract:
    An electrochemical immunoassay for the carcinoembryonic antigen is described. It is based on the use of Au NPs modified zeolitic imidazolate framework (ZIF-8) and ordered mesoporous carbon (OMC). Au NPs@ZIF-8 was synthesized by reduction of chloroauric acid. It serves as immobilization support nanocarrier to increase antibody loading due to its large surface area. OMC was dropped on a glassy carbon electrode to improve electrochemical signals due to enhanced electrical conductivity. Differential pulse voltammetry was carried out to record electrochemical responses (best measured at 0.26 V vs. Ag/AgCl). The immunosensor demonstrated excellent electrochemical performance with a linear determination range of 5 pg mL-1 to 400 ng mL-1 and a determination limit of 1.3 pg mL-1 (S/N = 3). The sensor also exhibited high selectivity, good stability, and acceptable reproducibility. Graphical abstract Scheme 1 Schematic representation of fabrication of the immunosensor for CEA determination.
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