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  • Title: Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population.
    Author: Shen C, Zhong Y, Huang X, Wang Y, Peng Y, Li K, Zhou B, Zhang L, Rao L.
    Journal: Biomark Med; 2020 Apr; 14(6):441-450. PubMed ID: 32270697.
    Abstract:
    Aim: The present study aimed to investigate the role of TAB2 gene polymorphisms in dilated cardiomyopathy (DCM) susceptibility and prognosis in a Chinese population. Materials & methods: A total of 343 DCM patients and 451 controls were enrolled and had their blood genotyped. Survival analysis was evaluated with Kaplan-Meier curves and Cox regression analysis. Results: G carriers (AG/GG) and AG genotype of rs237028 had a higher DCM susceptibility as well as a worse DCM prognosis. Additionally, C carriers (CT/CC) of rs652921 and G carriers (TG/GG) of rs521845 had a higher DCM risk and CC homozygote of rs652921 had a worse DCM prognosis. These associations were still significant after adjustment for the Bonferroni correction. Conclusion:TAB2 gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese population.
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