These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Growth hormone and somatomedin-C in bulimia.
    Author: Levy AB, Malarkey WB.
    Journal: Psychoneuroendocrinology; 1988; 13(4):359-62. PubMed ID: 3227091.
    Abstract:
    Somatomedin-C (SOM-C) concentrations are regulated by circulating growth hormone (GH) concentrations; however, other factors, such as nutrition, also influence SOM-C concentrations. We evaluated the GH-SOM-C axis in seven normal-weight female bulimics one day after hospital admission, and in seven age-, sex-, and weight-matched normal controls. Subjects were medication-free for at least one month. Fasting morning serum GH concentrations were higher in all bulimics (range 2.5-13.3 ng/ml) than in all controls (range less than 1.0-1.8 ng/ml). The mean (+/- SD) maximum GH response to TRH (500 micrograms) was greater in the bulimics (12.9 +/- 4.9 ng/ml) than in the controls (3.7 +/- 2.7 ng/ml) (p less than .001). Despite this GH elevation, the mean (+/- SD) SOM-C concentration was comparable in the bulimics (2.0 +/- 0.6 U/ml) and the controls (1.6 +/- 0.8 U/ml). This suggests that SOM-C generation is resistant to the elevated circulating GH in bulimia and that SOM-C is not inhibiting GH secretion in the pituitary-hypothalamic axis.
    [Abstract] [Full Text] [Related] [New Search]