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  • Title: Assembly and antifungal effect of a new fluconazole-carrier nanosystem.
    Author: de Lima TM, Arias LS, Afanaci LF, Ferraresse RF, de S Neto FN, de Lima BH, Straioto FG, de Camargo ER, Pessan JP, Monteiro DR.
    Journal: Future Microbiol; 2020 Mar; 15():273-285. PubMed ID: 32271112.
    Abstract:
    Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections.
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