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  • Title: [Antibodies to an antigen of human thymus epithelial tissue common to the epidermis of the skin in malignant myasthenia].
    Author: Gnezditskaia EV, Beletskaia LV, Shagal DI.
    Journal: Biull Eksp Biol Med; 1977 Jan; 83(1):60-2. PubMed ID: 322757.
    Abstract:
    It has been demonstrated by the indirect immunofluorecent technique that many of the sera of patients with myasthenia gravis react with the anticells of the human thymus epithelial tissue. Sorption of the sera with the suspension of the epidermis cells and the homogenates of the tissues of other human organs showed that the epithelial cell antigen with which the sera of patients with myasthenia reacted were epidermal heteroorganic thymus antigens, i.e. common for the thymus epithelium and skin epidermis. The presence of antibodies to the cells of the epithelial tissue of the thymus in the sera of patients suffering from myasthenia gravis permits to suppose the existence of an immunopathological process against the thymus tissue antigens (including the heteroorganic structures of its epithelium) in this disease.
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