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Title: Serum neutrophil chemotactic activity (NCA) during aspirin-induced urticaria and angioedema. Author: Grzelewska-Rzymowska I. Journal: Allergol Immunopathol (Madr); 1988; 16(4):231-6. PubMed ID: 3228043. Abstract: In order to establish the role of mast cells in aspirin-induced urticaria and angioedema, neutrophil chemotactic activity (NCA) in serum was assayed using the method of Nelson before and after aspirin challenge. In 14 (82.4%) persons sensitive to aspirin an increase in NCA during aspirin-induced urticaria and angioedema was observed and in 9 of them (52.9%) it was considerable (index NCA greater than or equal to 2.0). None of the 18 persons from the control group with idiopathic urticaria and/or angioedema but without aspirin-sensitivity exhibit an increase in NCA after aspirin challenge. The author assumes that mast cell degranulation does occur in aspirin-induced urticaria and angioedema.[Abstract] [Full Text] [Related] [New Search]