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  • Title: [The mechanisms of memory disorders at the stages in its acquisition and fixation].
    Author: Sprints AM.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1988 Oct; 74(10):1361-6. PubMed ID: 3229517.
    Abstract:
    The blockade of cholinergic system with scopolamine (10 mg/kg) did not impair the process of memory acquisition in rats but disrupted the process of memory fixation or consolidation, the disturbance stemming from the ketamine-blocked ion-channels of nicotinic receptors. Both scopolamine and ketamine impaired the process of memory recall, being more efficient in the case of ketamine. Piracetam (40 mg/kg) diminished the impair of fixation induced with scopolamine but did not affect the ketamine-induced impairment of memory acquisition.
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