These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cobalt-catalyzed 2-(1-methylhydrazinyl)pyridine-assisted cyclization of thiophene-2-carbohydrazides with maleimides: efficient synthesis of thiophene-fused pyridones.
    Author: Zhao H, Wang T, Qing Z, Zhai H.
    Journal: Chem Commun (Camb); 2020 May 21; 56(41):5524-5527. PubMed ID: 32296787.
    Abstract:
    A cobalt-catalyzed direct C-H/N-H functionalization of thiophene-2-carbohydrazides with maleimides by utilizing 2-(1-methylhydrazinyl)pyridine (MHP) as an easily removable bidentate directing group has been developed. This formal [4+2] cycloaddition has been achieved for the first time, and it provides an alternative and versatile approach to construct thiophene-fused pyridones using an inexpensive cobalt catalyst. The C-H/N-H activation cascade protocol showed a high efficiency and a broad substrate scope, and the products were obtained in good to excellent yields.
    [Abstract] [Full Text] [Related] [New Search]