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  • Title: Effect of sinus size and position on hemodynamics during pulsatile flow in a carotid artery bifurcation.
    Author: Nagargoje M, Gupta R.
    Journal: Comput Methods Programs Biomed; 2020 Aug; 192():105440. PubMed ID: 32299026.
    Abstract:
    BACKGROUND AND OBJECTIVES: Hemodynamics plays a crucial role in the progression of atherosclerosis and the treatment of arterial diseases. Stroke is one of the arterial diseases and a leading cause of death worldwide. Hemodynamics in the carotid artery plays a vital role in the stroke. The common carotid artery bifurcates into the internal carotid artery and the external carotid artery. Carotid sinus, a slightly dilated area, exists in the internal carotid artery just after the bifurcation and acts as a pressure receptor and regulator. The location and size of the sinus can vary in different people; the change in sinus size and location may affect the hemodynamics. It is necessary to study the shift in hemodynamics due to changes in sinus size and position on atherosclerosis. The change in flow behavior may suggest the probable sites of backflow and low wall shear stress, and therefore the sites prone to atherosclerosis. METHODS: The model of the carotid artery has been constructed using patient data. Transient computational fluid dynamics simulations have been performed using a finite volume method for the numerical solution in a three-dimensional computational domain using ANSYS Fluent 19.2. Pulsatile flow is specified at the inlet boundary. The coupled scheme is used for the pressure-velocity coupling. The second-order discretization scheme is used for pressure interpolation and second-order upwind scheme is used for the discretisation of momentum equation. The temporal term is discretized using the first-order implicit scheme. RESULTS: The effect of sinus size and location on the overall flow behavior, wall shear stress, and secondary flow are presented. Results show that the outer wall of bifurcation has low wall shear stress and bigger recirculation as compared with that on the inner wall of bifurcation. Numerical results obtained for varying sinus size and position are shown in graphs and contours, including wall shear stress, secondary flow, and velocity streamlines. CONCLUSION: Numerical results reveal that sinus away from bifurcation, and larger diameter sinus has more recirculation and low wall shear stress. Therefore, the person having sinus away from bifurcation and larger sinus diameter are more susceptible to plaque formation.
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