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  • Title: Protection against carbon tetrachloride-induced hepatotoxicity by protein A.
    Author: Singh KP, Saxena AK, Zaidi SI, Dwivedi PD, Srivastava SP, Seth PK, Ray PK.
    Journal: J Appl Toxicol; 1988 Dec; 8(6):407-10. PubMed ID: 3230253.
    Abstract:
    Protection from carbon tetrachloride (CCL4)-induced hepatotoxicity by protein A was assessed histologically in rats. Carbon tetrachloride exposure produced swollen, vacuolated and necrotic cells in the centrilobular region of the hepatocyte in rats. Animals given protein A prior to and during CCL1 treatment showed a complete absence of hepatic lesions. Our study showed that protein A, a potent immunomodulator, has the potential to reduce liver injury caused by carbon tetrachloride, a known hepatotoxin in the rat.
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