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  • Title: Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides.
    Author: Wang XF, Zhu Z, Hao TT, Fang QQ, Jiang K, Qu SJ, Zuo JP, Zhu W, He SJ, Tan CH.
    Journal: Bioorg Chem; 2020 Jun; 99():103812. PubMed ID: 32302796.
    Abstract:
    Alopecines A-E (1-5), five unusual matrine-type alkaloids featuring with an additional dichlorocyclopropane (1-3) or a di/tri-chloromethyl (4/5) attached on the D ring, were isolated from the seeds of Sophora alopecuroides. Their structures and absolute configurations were elucidated by extensive spectroscopic techniques, and X-ray diffraction analyses or time-dependent density functional theory-based electronic circular dichroism (TDDFT-ECD) calculations. Alkaloid 4 exhibited potent inhibitory effects on the proliferation of ConA-induced T lymphocytes or LPS-induced B cells with IC50 value of 3.98 or 3.74 μM, respectively.
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