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  • Title: Pituitary response to luteinizing hormone-releasing hormone after induced abortion in the first and second trimesters.
    Author: Domenzain ME, Shapiro AG, Bezjian AA, LeMaire WJ.
    Journal: Fertil Steril; 1977 May; 28(5):531-4. PubMed ID: 323073.
    Abstract:
    Luteinizing hormone-releasing hormone (LHRH) (100 microng) was administered subcutaneously to healthy female volunteers 2 and 4 weeks after induced abortion in the first trimester (group A) and the midtrimester (group B). Four patients were studied in each group. The response to LHRH was determined in terms of plasma LH and follicle-stimulating hormone levels. Adequate pituitary response occurred in subjects of group A at both 2 and 4 weeks. In group B pituitary unresponsiveness was found at 2 weeks which persisted to some extent at 4 weeks. These data are in accord with the pituitary unresponsiveness observed after termination of pregnancy at term and suggest that the duration of pregnancy has an influence on the development of this unresponsiveness. The response of luteinizing hormone (LH) and follicle stimulating hormone (FSH) to 100 mcg LH-releasing hormone (LH-RH), administered sc at 2 and 4 weeks after either first trimester or midtrimester aborting, was studied. Those abortion in the first trimester showed an adequate pituitary response at 2 and 4 weeks, while those aborting in midtrimester failed to show an adequate response at 2 weeks which continued, in some cases, to 4 weeks. The results suggest that the duration of pregnancy had an influence on the response of pituitary gonadotropins to LH-RH following abortion.
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