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  • Title: [Value of determining serum enzyme activity during the exercise test in evaluating the functional condition of patients with ischemic heart disease and concomitant diabetes mellitus].
    Author: Nikolaeva LF, Azhmukhanbetova AZh, Titov VN, Perelygina AA.
    Journal: Kardiologiia; 1988 Nov; 28(11):85-90. PubMed ID: 3230784.
    Abstract:
    Exercise-induced changes in the activity of serum lactate dehydrogenase (LDG) and its isoenzymes, CK, aspartate and alanine aminotransferase, were examined in postmyocardial-infarction coronary patients with second-type diabetes mellitus and 18 chronic coronary patients with second-type diabetes mellitus. Patients from both groups showed increased total LDG and LDG-5 activity at rest and reduced total LDG, LDG-1, LDG-2 and LDG-3 activity in response to exercise, which may be an evidence of prevailing anaerobic glycolysis as a manifestation of tissue hypoxia. Rationed bicycle ergometric exercise produces no rise in blood CK, aspartate and alanine aminotransferase activities in coronary patients with second-type diabetes mellitus, suggesting that exercise of this kind has no damaging effect on myocardial and skeletal-muscle myocytes.
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