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  • Title: Discoveries and Challenges en Route to Swinhoeisterol A.
    Author: Duecker FL, Heinze RC, Steinhauer S, Heretsch P.
    Journal: Chemistry; 2020 Aug 06; 26(44):9971-9981. PubMed ID: 32315103.
    Abstract:
    In this work, a full account of the authors' synthetic studies is reported that culminated in the first synthesis of 13(14→8),14(8→7)diabeo-steroid swinhoeisterol A as well as the related dankasterones A and B, 13(14→8)abeo-steroids, and periconiastone A, a 13(14→8)abeo-4,14-cyclo-steroid. Experiments are described in detail that provided further insight into the mechanism of the switchable radical framework reconstruction approach. By discussing failed strategies and tactics towards swinhoeisterol A, the successful route that also allowed an access to structurally closely related analogues, such as Δ22 -24-epi-swinhoeisterol A, is eventually presented.
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