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  • Title: A coumarin-based fluorescent probe for Hg2+ and its application in living cells and zebrafish.
    Author: Li X, Duan Q, Yu Y, Wang K, Zhu H, Zhang X, Liu C, Jia P, Li Z, Sheng W, Zhu B.
    Journal: Luminescence; 2020 Sep; 35(6):941-946. PubMed ID: 32324318.
    Abstract:
    Mercury (Hg) is a heavy metal with high toxicity and easy migration; it can be enriched through the food chain, and cause serious threats to the natural environment and human health. So, the development of a method that can be used to detect mercury ions (Hg2+ ) in the environment, in cells, and in organisms is very important. Here, a new 7-hydroxycoumarin-derived carbonothioate-based probe (CC-Hg) was designed and synthesized for detection of Hg2+ . After addition of Hg2+ , a large fluorescence enhancement was observed due to the formation of 7-hydroxyl, which reinforced the intramolecular charge transfer process. The CC-Hg probe had good water solubility and selectivity. Moreover, the probe was able to detect Hg2+ quantitatively over the concentration range 0-2 μM and with a detection limit of 7.9 nM. Importantly, we successfully applied the probe to detect Hg2+ in water samples, in living cells, and in zebrafish. The experimental results demonstrated its potential value in practical applications.
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