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  • Title: Total Synthesis of Fawcettimine-Type Alkaloid, Lycojaponicumin A.
    Author: Shao H, Fang K, Wang YP, Zhang XM, Ding TM, Zhang SY, Chen ZM, Tu YQ.
    Journal: Org Lett; 2020 May 15; 22(10):3775-3779. PubMed ID: 32330061.
    Abstract:
    The efficient total synthesis of lycojaponicumin A (1) has been accomplished for the first time. The remarkable features of this novel strategy include the following: (1) rapid construction of tricyclic intermediate 4 through a regio- and stereoselective semipinacol ring expansion, which simplified the construction of rings A and B of 1; (2) the subsequent regio- and stereoselective formation of the highly strained rings C-E of 1 through a tandem oxa-hetero [3 + 2] cycloaddition/N-cycloalkylation.
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