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  • Title: Distribution of distances in thiopeptides by fluorescence energy transfer and frequency-domain fluorometry.
    Author: Wiczk WM, Gryczynski I, Szmacinski H, Johnson ML, Kruszynski M, Zboinska J.
    Journal: Biophys Chem; 1988 Oct; 32(1):43-9. PubMed ID: 3233313.
    Abstract:
    Frequency-domain fluorescence spectroscopy was employed to examine the decays of tryptophan in Boc-Trp-Met-Asp-Phe-NH2 (donor) and (Formula: see text) (donor-acceptor pair). The efficiency of energy transfer in the thiopeptide amounted to 60%. The measured dispersion of fluorescence decay times was used to recover the donor-acceptor distance distribution. The parameters of the Gaussian distance distribution obtained for this peptide (r, the mean distance (9 A); hw, the halfwidth (25 A)) indicate the lack of a distinct favorable conformation.
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