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  • Title: Expression of muscle actin genes in early differentiation stages of tail regeneration of the urodele amphibian Pleurodeles waltlii.
    Author: Khrestchatisky M, Djabali M, Thouveny Y, Fontes M.
    Journal: Cell Differ Dev; 1988 Dec; 25(3):203-12. PubMed ID: 3233536.
    Abstract:
    Amputation of the tail of the amphibian Pleurodeles waltlii leads to the formation of a blastema composed of undifferentiated cells during the first stages of regeneration. Between the 3rd and 4th week following amputation, the first fully differentiated striated muscle cells appear, and in the 6th week myogenic differentiation extends throughout the regenerate. Myoblasts appear in cell patches where cells fuse as differentiation proceeds. Using a cloned cDNA probe to a striated muscle actin gene specifically expressed in adult skeletal muscle, we show that no corresponding mRNA remains during dedifferentiation. A new actin transcript of the same length as cardiac actin transcript appears in the 4th week after amputation. We conclude that for the myogenic cell line, differentiation in the regenerate is accompanied by an actin isoform transition similar to that seen in embryonic terminal differentiation of higher vertebrates.
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