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  • Title: Solubility of codeine phosphate in carbitol + 2-propanol mixture at different temperatures.
    Author: Rezaei H, Jouyban A, Martinez F, Barzegar-Jalali M, Rahimpour E.
    Journal: Drug Dev Ind Pharm; 2020 Jun; 46(6):910-915. PubMed ID: 32339003.
    Abstract:
    The solubility profile of codeine phosphate in the carbitol and 2-propanol mixtures at 293.2-313.2 K are determined and correlated with some developed cosolvency models. Moreover, the density values of codeine phosphate saturated solutions are also determined and fitted with the Jouyban-Acree model. The model accuracy is investigated by calculating the mean relative deviations (MRDs%). The thermodynamic parameters of codeine phosphate dissolution in the non-aqueous mixtures of carbitol and 2-propanol are also computed by using van't Hoff and Gibbs equations.
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