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  • Title: [Interaction of the calcium salt of heparin with specific antagonists and ethacizine].
    Author: Ushkalova EA, Petrov AD, Kremneva VF, Shcheglova NV.
    Journal: Farmakol Toksikol; 1988; 51(6):53-6. PubMed ID: 3234542.
    Abstract:
    Protamine sulfate was shown to bind calcium heparinate isolated from the pig intestinal mucosa during in vitro experiments in 0.6:1 ration and during experiments on rabbits and dogs in 1.5:1 ratio. 2,5-ionen neutralizes the anticoagulant effect of calcium heparinate during in vitro and animal experiments in 0.6:1 ratio. Neutralization of calcium heparinate requires by approximately 30% more specific antagonists than neutralization of the same amount of sodium heparinate. Ethacizine was found in experiments on rabbits to decrease the anticoagulant effect of calcium heparinate to the same degree as does sodium heparinate.
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