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  • Title: Calcium dobesilate and its effects on hemorheology and microcirculation.
    Author: Költringer P, Eber O, Rothlauer W, Klima G, Lind P, Langsteger W, Wakonig P.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1988 Oct; 26(10):500-2. PubMed ID: 3235217.
    Abstract:
    In series, 50 patients suffering from cerebral (n = 33) and peripheral (n = 17) diseases were treated with 3 x 500 mg calcium dobesilate (Doxium) per day. Before onset of therapy and after 14 days the viscoelasticity of whole blood and plasma as well as hematocrit and microcirculation at the finger pad were measured. Viscoelasticity of whole blood, plasma and hematocrit decreased in a significant manner (p less than or equal to 0.001), while microcirculation increased significantly (p less than or equal to 0.001). The results justify the application of calciumdobesilate for ischemic diseases with elevated viscosity.
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