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  • Title: Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan.
    Author: Chu CN, Wang YC, Chang WS, Wang ZH, Liu LC, Wang SC, Lin CC, Liu TY, Chang JG, Tsai CW, Yu CC, Bau DT.
    Journal: In Vivo; 2020; 34(3):1111-1116. PubMed ID: 32354899.
    Abstract:
    BACKGROUND/AIM: The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese. MATERIALS AND METHODS: A total of 1232 breast cancer patients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. RESULTS: Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were not differentially distributed between case and control groups. Consistently, there was no difference in the distribution of allelic frequencies among patients and controls. CONCLUSION: IL-4 rs2243248, rs2243250 and rs2070874 do not confer breast cancer susceptibility in Taiwanese.
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