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  • Title: Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer.
    Author: Wu MF, Wang YC, Shen TC, Chang WS, Li HT, Liao CH, Gong CL, Wang ZH, Tsai CW, Hsia TC, Bau DT.
    Journal: In Vivo; 2020; 34(3):1117-1123. PubMed ID: 32354900.
    Abstract:
    BACKGROUND/AIM: Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility. MATERIALS AND METHODS: IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancer patients and 716 controls via the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology. RESULTS: The highlight finding is that the distributions of genotypic (p=8.6E-10) and allelic (p=0.0001) frequencies of IL-16 rs11556218 was significantly different between cases and controls. In detail, the frequencies of IL-16 rs11556218 heterozygous variant TG and homozygous variant GG were 36.6 and 7.3% among the lung cancer patients, significantly higher than those among the controls (22.5% and 2.6%). On the other way, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. CONCLUSION: The present study indicates IL-16 rs11556218 G allele is significantly associated with increased Taiwan lung cancer risk.
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