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  • Title: Determination of digoxin in serum by on-line immunoadsorptive clean-up high-performance liquid chromatographic separation and fluorescence-reaction detection.
    Author: Reh E.
    Journal: J Chromatogr; 1988 Dec 09; 433():119-30. PubMed ID: 3235540.
    Abstract:
    The use of valve-switching with an anti-digoxin immunoadsorptive clean-up cartridge prior to reversed-phase elution of serum is described. Eluted digoxin is detected by reaction of the unsplit eluent stream with hydrochloric acid in a PTFE coil, followed by fluorescence detection. Routes for optimization and evaluation of the immunoadsorptive clean-up are reported, and the effects on the recovery rate examined. The detection limit of 300 pg/ml and reproducibility of less than 7% for the application of the analytical procedure to serum are reasonably good.
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