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  • Title: Mutagenicities of quinoline and its derivatives.
    Author: Nagao M, Yahagi T, Seino Y, Sugimura T, Ito N.
    Journal: Mutat Res; 1977 Mar; 42(3):335-42. PubMed ID: 323699.
    Abstract:
    Quinoline, recently reported to be carcinogenic in rats [12], was mutagenic to Salmonella typhimurium tester strains TA100 and TA98 in the presence of the metabolic activation system S-9 mix. 2-Chloroquinoline, a non-carcinogen [12], was non-mutagenic with or without S-9 mix. 8-Hydroxyquinoline, which is t known to be carcinogenic, was mutagenic with S-9 mix to both bacterial strains. The mutagenicities of 17 other quinoline derivatives that are not known to be carcinogenic were tested, and 12 of these compounds were mutagenic.
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