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  • Title: The effect of buthobendin on glycolysis in rabbit myocardial slices in vitro.
    Author: Marchut E, Gumińska M, Kedryna T.
    Journal: Pol J Pharmacol Pharm; 1988; 40(2):167-72. PubMed ID: 3237566.
    Abstract:
    The effect of buthobendin (2S,2'S isomer of N,N'-dimethyl N,N'-bis[1-(3',4',5'-trimethoxybenzoyloxy)-butyl-2]-ethylenediamin e dihydrochloride), (CravitenR) on aerobic and anaerobic glycolysis in rabbit myocardial slices was compared with that of the biologically inactive isomer 2R,2'R and the well-known antiarrhythmic drugs quinidine and procainamide. Only buthobendin stimulated lactate formation under anaerobic and aerobic conditions. However, that effect was not accompanied with a parallel increase in the glucose uptake, but was related to a decrease in the glycogen level. This finding might indicate that buthobendin stimulates glycolysis by mobilization of the glycogen degradation.
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