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  • Title: [Expression of high mobility group protein B1 in periodontal tissues and its association with hepatic lipid metabolism in diabetic rats with periodontitis].
    Author: Pei X, Meng S, Gou C, Du Q.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2020 Jan 30; 40(1):6-12. PubMed ID: 32376562.
    Abstract:
    OBJECTIVE: To investigate the expression of high mobility group box-1 protein (HMGB1) and its downstream products, receptor for advanced glycation end-products (RAGE) and tumor necrosis factor-α (TNF-α), in periodontal tissues of diabetic rats with periodontitis, and explore the association of HMGB1 with hepatic lipid metabolism. METHODS: Immunohistochemical staining was used to detect the expression of HMGB1, RAGE and TNF-α in the periodontal tissues in rat models of diabetes mellitus (DM), periodontitis (CP), and diabetic periodontitis (DM + CP). The serum levels of the indicators of lipid metabolism and biochemical indexes of liver damage were detected by spectroscopy. RESULTS: The expressions of HMGB1 and RAGE in the periodontal tissues were significantly higher in DM group than in the control group, but the expression of TNF-α showed no significant difference among the groups. In CP group, the expressions of HMGB1 and TNF-α were significantly higher than those in the control group, and the expression of RAGE was comparable with that in the control group but significantly lower than that in DM and DM+CP group. The expressions of HMGB1, RAGE and TNF-α were all significantly higher in DM+CP group than in the control group. Compared with the control rats, the rats in DM, CP, DM+CP group all showed abnormal hepatic lipid metabolism with significantly elevated serum ALT levels. CONCLUSIONS: HMGB1 and RAGE participate in the inflammation of the periodontal tissues in diabetic rats. Diabetes leads to elevated expression of HMGB1 in the periodontal tissues. Both periodontitis and hyperglycemia contribute to liver metabolic dysfunction. HMGB1- RAGE provides clues in the study of signaling pathways underlying the mutual susceptibility of diabetes and periodontitis. 目的: 探讨高迁移率族蛋白B1（HMGB1）与其下游的晚期糖基化终产物受体（RAGE），肿瘤坏死因子α（TNF-α）在糖尿病及牙周炎大鼠牙周组织中的表达，及与免疫代谢重要器官肝脏脂代谢之间的关系。 方法: 建立糖尿病（DM）、牙周炎（CP）、糖尿病复合牙周炎（DM+CP）大鼠模型。免疫组化染色检测牙周组织中HMGB1、RAGE、TNF-α的表达，光谱法检测血清中的脂代谢相关指标和肝损生化指标，并进行统计学分析。 结果: DM组大鼠牙周组织中HMGB1，RAGE表达显著性高于对照组（P < 0.05），TNF-α表达量与对照组无差异；CP组HMGB1及TNF-α表达显著性高于对照组，RAGE表达显著性低于DM及DM+CP组，与对照组无显著性差异；DM+CP组大鼠牙周组织中HMGB1，RAGE，TNF-α表达均高于对照组。与对照组相比较，DM，CP，DM+CP组可见多项肝脏脂代谢指标异常，其中肝脏损伤指标ALT表达在3组中均显著性升高（P < 0.05）。 结论: HMGB1，RAGE参与糖尿病大鼠的牙周组织炎症进程，糖尿病导致牙周组织中HMGB1表达升高。在高血糖、牙周炎及高血糖复合牙周炎情况下，均能导致一定程度的肝脏代谢功能紊乱，HMGB1-RAGE为解释糖尿病与牙周炎互为易感的信号通路研究提供了一定的线索。
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