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  • Title: Synthesis and biological activity of some new pyrimidine and thienopyrimidine derivatives.
    Author: el-Bahaie S, Kadry AM, Assy MG, Ibrahim YA.
    Journal: Pharmazie; 1988 Aug; 43(8):537-8. PubMed ID: 3237742.
    Abstract:
    The readily available 4-mercapto-6-methyl-2-phenyl-5-acetylpyrimidine (1) was alkylated with a variety of activated halomethylene compounds to give the corresponding thieno [2,3-d] pyrimidine derivatives 3a-h via the intermediate alkylmercaptopyrimidine derivatives 2b-h. The biological activity of the new compounds was screened against several strains of bacteria.
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