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  • Title: Pulmonary single circulation dilution curves of T-1824, sodium, and tritiated water in intact piglets.
    Author: Levine OR, Bansil E.
    Journal: Pediatr Res; 1977 May; 11(5):681-4. PubMed ID: 323809.
    Abstract:
    In order to assess pulmonary endothelial permeability to sodium in the immature lung, 15 multiple indicator dilution curves were done in eight intact piglets. An indicator bolus consisting of T-1824, 22Na, and tritiated water (THO) was delivered into the right atrium and blood was sampled from the aorta. The concentration of sodium, expressed as a fraction of the quantity injected and of the corresponding fractional concentration of T-1824, was averaged for the samples prior to recirculation. The permeability-surface area product calculated from these data is 2.0 X 10(-5) cm sec-1, and is virtually identical with the value reported elsewhere for adult dogs. Extravascular lung water obtained from the triated water and T-1824 curves averaged 64%, whereas that obtained from the 22Na and T-1824 curves averaged 23% of blood-free lung water.
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