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  • Title: Epidemiological and genetic study of 200 cases of oral cleft in the Emilia Romagna region of northern Italy.
    Author: Calzolari E, Milan M, Cavazzuti GB, Cocchi G, Gandini E, Magnani C, Moretti M, Garani GP, Salvioli GP, Volpato S.
    Journal: Teratology; 1988 Dec; 38(6):559-64. PubMed ID: 3238612.
    Abstract:
    Epidemiological and genetic variables in clefts were analyzed during the years 1978-1986 in a case-control study of congenital malformations in the Emilia Romagna region of northern Italy. Among 150,168 newborns, 200 cases of cleft were detected, yielding a prevalence of 1.33 per 1,000. These clefts consisted of 112 (0.075%) cases of cleft lip with or without cleft palate (CL +/- P) and 88 cases (0.058%) of cleft palate (CP). Coexisting abnormalities were found in 32% of cases. The heritability coefficient of CL +/- P was 0.84. No cluster in time or space could be demonstrated. Epilepsy was the only maternal risk factor found to be correlated with clefts. A predominance of males was found among CL +/- P cases.
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