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  • Title: [The effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria].
    Author: Koshkin VV.
    Journal: Ukr Biokhim Zh (1978); 1988; 60(6):79-82. PubMed ID: 3238802.
    Abstract:
    Effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria is described. State 3 respiration is inhibited by acetoacetate, while state 4 respiration is not inhibited, though cytochrome c reduction was decreased. Acetoacetate is also non-competitive inhibitor of 3-hydroxybutyrateoxidase and 3-hydroxybutyrate dehydrogenase activity in frozen-thawed mitochondria. The results are discussed in terms of the thermodynamic hypothesis and control strength method.
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