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  • Title: [The mechanism of activation of kallikrein-kinin system in the plasma of patients with atopic allergic diseases].
    Author: Dotsenko VL, Nenasheva NM, Neshkova EA, Morozova NA, Iarovaia GA.
    Journal: Vopr Med Khim; 1988; 34(6):89-94. PubMed ID: 3238945.
    Abstract:
    Data early obtained on activation of the kallikrein-kinin system in acute forms of pollinosis and urticaria were corroborated in vitro. These experiments exhibited enzymatic activation of Hageman factor and prekallikrein using "liberator", obtained after incubation of the leukocyte fraction enriched with basophils and specific allergen. I ml of the "liberator" containing 10(7) cells activated Hageman factor up to 12-20 mU per min (evaluated by BAEE-esterase activity of the kallikrein developed) as well as kallikrein activity was increased up to 80-130 mU within 1.5-2 hrs of incubation. The Hageman factor was distinctly inactivated after long-term incubation with the "liberator".
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