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  • Title: [Analysis of medication characteristics of traditional Chinese medicine in treating COVID-19 based on data mining].
    Author: Fan T, Chen Y, Bai Y, Ma F, Wang H, Yang Y, Chen J, Lin Y.
    Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban; 2020 May 25; 49(2):260-269. PubMed ID: 32391675.
    Abstract:
    OBJECTIVE: To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). METHODS: We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak to February 19, 2020. The frequency analysis, cluster analysis and association analysis were performed. RESULTS: The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. The high frequently used herbs were Liquorice, Scutellariabaicalensis, Semen armeniacaeamarae, and Gypsum. The commonly used traditional formulations included Maxing Shigan decoction, Yin Qiao powder, and Xuanbai Chengqi decoction. The Chinese patent drugs included Angong Niuhuang pill, Xuebijing injection, and Lianhua Qingwen capsule. The most common paired medications were Ephedra and Semen armeniacaeamarae, Fructusforsythiae and Liquorice. Two core combinations and one novel formula were discovered in the study. CONCLUSIONS: Yin Qiao powder and Huopo Xialing decoction are the basic formulations for Weifen syndrome of COVID-19. In addition, Maxing Shigan decoction, Liang Ge powder, Qingwen Baidu decoction and Da Yuan decoction are the basic formulations for Qifen syndrome of COVID-19. The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. It shows that removing toxicity and eliminating evil are the prescription thought in treating epidemic disease of traditional Chinese medicine. 目的: 分析国家卫生健康委员会（卫健委）、国家中医药管理局（中管局）及各省市自治区卫健委、中管局通过公开渠道发布的2019冠状病毒病（COVID-19）治疗方案中中医药处方用药特点。 方法: 收集自我国COVID-19疫情发生以来至2020年2月19日国家及各省市自治区卫健委、中管局通过公开渠道发布的COVID-19推荐诊疗方案中中医药相关内容，并进行所有数据的频数分析、关联分析和聚类分析。 结果: 共收集国家诊疗方案4个，各省市自治区防治方案34个，样本578条，得到有名称的传统方剂84首，中成药60种，涉及单味药230味。高频用药有甘草、黄芩、杏仁、石膏等，常见方剂有麻杏石甘汤、银翘散、宣白承气汤等，常用中成药有安宫牛黄丸、血必净注射液、连花清瘟胶囊等，高频药对有“麻黄，杏仁”“连翘，甘草”等，挖掘出核心药物组合2个，新处方1个。 结论: COVID-19卫分证以银翘散、藿朴夏苓汤为基础方，气分证可以麻杏石甘汤、凉膈散、清瘟败毒饮、达原饮等为基础方。用药特点以宣肺清热、解毒祛浊为主，体现中医治疫解毒透邪的处方思路。
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