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  • Title: Acute monoblastic leukemia with osteosclerosis and extensive myelofibrosis.
    Author: Janin A, Nelken B, Dufour S, Sault MC, Taboureau O, Zandecki M, Gosselin B.
    Journal: Am J Pediatr Hematol Oncol; 1988; 10(4):319-22. PubMed ID: 3239709.
    Abstract:
    A 4-month-old infant was admitted with a monoblastic infiltration of the skin associated with osteosclerosis. Both lesions spontaneously disappeared within a few months, but 2 years later, a monoblastic leukemia occurred that was associated with marked skin erythema and myelofibrosis. Skin and bone marrow specimens showed a monoblastic infiltration with numerous intermingled mast cells of normal appearance. Whether myelofibrosis was a feature of a systemic mastocytosis or of the leukemic process is discussed in this case.
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