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  • Title: [Effect of metabolic changes in the liver on the cytotoxic activity of cyclophosphamide in the incisor of rats].
    Author: Rosenfeld E, Ponsold W, Hoffmann P.
    Journal: Biomed Biochim Acta; 1988; 47(8):761-6. PubMed ID: 3240306.
    Abstract:
    The incisor of the rat is a sensitive biological indicator which records nutritive and hormonal disorders as well as toxic influences. The present investigation was aimed to provide information whether or not the manifestation of cyclophosphamide-caused hypoplasias could be altered by an induction (phenobarbital) or inhibition (carbon tetrachloride) of the liver biotransformation capacity. Cyclophosphamide (15 or 30 mg/kg) was injected intraperitoneally. Pretreatment of the rat with phenobarbital produced an increase (35%) of the malformation, whereas carbon tetrachloride led to a dose dependent decrease (30 or 50%). Our investigations suggest that the cyclophosphamide induced defect of the incisor is due to an alteration of the metabolic liver function.
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