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  • Title: Synthesis and study of phosphoenolthiopyruvate.
    Author: Sikkema KD, O'Leary MH.
    Journal: Biochemistry; 1988 Feb 23; 27(4):1342-7. PubMed ID: 3240340.
    Abstract:
    Phosphoenolthiopyruvate, the analogue of phosphoenolpyruvate in which the bridging oxygen of the phosphate ester is replaced by sulfur, has been synthesized from methyl acrylate and dimethyl (chlorothio)phosphonate. The compound is a substrate for alkaline phosphatase, pyruvate kinase, enolase, and phosphoenolpyruvate carboxylase. Both pyruvate kinase and phosphoenolpyruvate carboxylase convert the compound to thiopyruvate, which is a substrate for lactate dehydrogenase. Phosphoenolpyruvate carboxylase is slowly inactivated by phosphoenolthiopyruvate.
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