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  • Title: Effect of calcitonin on hepatic drug metabolism.
    Author: Godinho AF, Cavalcante GJ, Machado MG, Faria TF, Gil TC, Coutinho RB, Garcia C.
    Journal: Braz J Med Biol Res; 1988; 21(4):851-3. PubMed ID: 3240382.
    Abstract:
    A single dose of calcitonin (150 mIU/100 g body weight, sc) produced a significant decrease in liver antipyrine hydroxylase and aminopyrine demethylase activities. By contrast, pentobarbital sleeping time was not altered by calcitonin treatment. The present results indicate that acute calcitonin administration depresses the metabolism of substrates of the mixed function oxidase system of rat liver.
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