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Title: Gelatin-crosslinked pectin nanofiber mats allowing cell infiltration. Author: Shi X, Cui S, Song X, Rickel AP, Sanyour HJ, Zheng J, Hu J, Hong Z, Zhou Y, Liu Y. Journal: Mater Sci Eng C Mater Biol Appl; 2020 Jul; 112():110941. PubMed ID: 32409087. Abstract: Pectin nanofiber mats are promising tissue engineering scaffolds but suffer from poor cell infiltration. In this study, gelatin, a collagen derived cell adhesive protein, was used to crosslink the electrospun nanofibers of periodate oxidized pectin. Cell culture experiment results demonstrated that cells were able to grow into the gelatin-crosslinked pectin nanofiber mats rather than only spread on mat surface. The nanofiber mats showed moderate mechanical strength, with a maximum tensile strength of up to 2.3 MPa, an ultimate tensile strain of up to 15%, and were capable of degrading gradually over 4 weeks or even longer periods in simulated body fluids. Thus, gelatin-crosslinked pectin nanofiber mats hold a great potential for soft tissue regeneration.[Abstract] [Full Text] [Related] [New Search]